Pharm Ingredients
Buy Mangiferin Powder
What is Mangiferin Powder?
Mangiferin is a flavonoid compound originally extracted primarily from mangoes, but it has subsequently been discovered in the roots, stems, leaves, flowers, fruits, and bark of various other plants, including Anemarrhena asphodeloides, mangifera indica l., kapok, and coffee. Notably, mangoes and Anemarrhena asphodeloides exhibit relatively high concentrations of mangiferin. Research indicates that mangiferin possesses a wide range of pharmacological activities, including therapeutic potential against cancer, cardiovascular diseases, diabetes, and neurodegenerative disorders. Its biological activity is primarily mediated through mechanisms such as antioxidant effects, free radical scavenging, and immunomodulation.
Why Choose Kintainutri® Mangiferin Powder?
Specification of kintainutri® mangiferin powder
Kintainutri® possesses its own core technologies and invention patents. The mangiferin produced by Kintainutri® is a natural active ingredient extracted from mango leaves and fruit. Possessing antioxidant, anti-inflammatory, and hepatoprotective properties, it holds broad application prospects across the pharmaceutical, health supplement, and cosmetic sectors.We offer mangiferin powder with a purity level of 60%, 95%, 98%, as well as 15% water-soluble Mangiferin, and also provide customized services, if you are looking to procure mangiferin powder in bulk, we invite you to consider Kintainutri® products.
| Product Name | Extraction Sources | Specifications |
|---|---|---|
| Mangiferin Powder | Mango Leaf | 60% |
| 95% | ||
| 98% |
Mangiferin powder patent and HPLC report
Mangiferin powder packaging
Mangiferin Powder Benefits
Mangiferin cancer
Mangiferin exhibits potential anticancer activity through multiple mechanisms. It may inhibit NF-κB- and COX-2-mediated inflammatory responses, thereby interfering with the formation of a tumor-supportive microenvironment. In addition, it has been reported to modulate the MAPK signaling pathway and induce G₂/M cell cycle arrest, which may contribute to the suppression of cancer cell proliferation and metastasis.
Mangiferin powder may also activate mitochondrial and extrinsic apoptotic pathways, promoting apoptosis in cancer cells. Furthermore, it has demonstrated the ability to activate the Nrf2/ARE pathway, helping to scavenge reactive oxygen species (ROS) and reduce oxidative stress-related damage. Emerging evidence suggests that mangiferin may enhance the sensitivity of cancer cells to certain chemotherapeutic agents, such as oxaliplatin and etoposide, while potentially alleviating associated toxic effects, highlighting its promise as a candidate for further research in adjunctive cancer therapy.
Mangiferin for liver health support
Through multiple biological pathways, mangiferin demonstrates potential anticancer activity. In a model of carbon tetrachloride-induced acute liver injury, mangiferin reduces serum levels of transaminases (ALT and AST) and alkaline phosphatase, while attenuating hepatocyte necrosis and inflammatory infiltration. In cases of ethanol-induced liver injury, mangiferin powder restores the activity of hepatic antioxidant enzymes (SOD, CAT, and GPx), lowers malondialdehyde levels, and alleviates oxidative stress.
Its mechanism of action involves activating the Nrf2 signaling pathway to bolster the antioxidant defense system, while simultaneously inhibiting NF-κB-mediated inflammatory responses. Consequently, it demonstrates protective efficacy against both alcohol-induced and chemically induced liver injuries. These characteristics position our mangiferin powder as a promising ingredient for the development of functional foods and hepatoprotective supplements.
Renoprotective effects of mangiferin
Research findings suggest that mangiferin may support renal health by alleviating kidney injury triggered by inflammatory, metabolic, and oxidative stress-related factors. In a rat model of diabetic nephropathy, mangiferin reduces urinary albumin excretion rates, as well as blood urea nitrogen and creatinine levels, while inhibiting glomerular basement membrane thickening and extracellular matrix accumulation. In a model of sepsis-induced acute kidney injury, mangiferin lowers serum levels of IL-1β and IL-18, suppresses NLRP3 inflammasome activation, and reduces apoptosis in renal tubular epithelial cells.
Furthermore, mangiferin powder promotes uric acid excretion by regulating uric acid transporters, thereby ameliorating hyperuricemia and associated kidney injury, this positions our mango leaf extract as a promising functional ingredient candidate for the protection of renal function and the management of metabolic syndrome complications.
Mango leaf extract diabetes
Mangiferin has shown promise in supporting glucose and lipid metabolism through the modulation of multiple molecular targets. Studies indicate that mangiferin powder inhibits α-glucosidase activity, thereby delaying carbohydrate absorption; promotes free fatty acid oxidation by activating the PPARα pathway, which improves insulin resistance; and simultaneously modulates the Nrf2/ARE signaling pathway to alleviate high-glucose-induced oxidative stress and inflammatory responses.
Furthermore, mangiferin extract reduces serum total cholesterol levels and ameliorates lipid metabolic disorders associated with diabetes. These multifaceted mechanisms position mangiferin as a promising ingredient within the fields of functional foods and botanical extracts for use in blood glucose management and the intervention of metabolic syndrome.
source: https://pubmed.ncbi.nlm.nih.gov/33601215/
Mangiferin Powder Uses
Mango leaf extract supplement
Health product manufacturers can add mangiferin powder to liver-nourishing and protective supplements. It can help promote liver metabolism and reduce liver burden, making these products suitable for those who frequently stay up late or drink alcohol. It can also be added to antioxidant supplements, where its antioxidant properties help fight free radicals and slow the decline of bodily functions.
Mangiferin for cosmetic
Cosmetics manufacturers can incorporate mangiferin powder into soothing and repairing skincare products to alleviate redness and sensitivity caused by external irritants and strengthen the skin's barrier function. Adding mangiferin powder to whitening skincare products can also help reduce melanin deposition, resulting in a more even and translucent complexion.
Mangiferin in pharmaceutical applications
Pharmaceutical manufacturers can leverage mangiferin powder's anti-inflammatory and metabolic properties to develop related drugs. For example, adding an appropriate amount of mangiferin powder to diabetes medications can help regulate blood sugar levels. Adding it to medications for inflammatory diseases can enhance anti-inflammatory effects and help alleviate symptoms.
Mangiferin Powder Dosage
In human pharmacokinetic studies, a single oral dose of mangiferin administered to healthy subjects was approximately 480 mg. The specific dosing regimen consisted of approximately 780–805 mg of mangiferin extract (containing 60% mangiferin), taken with 250 mL of water under fasting conditions. Based on body weight, the dose was approximately 5.8 mg/kg for male subjects (average 83.5 kg) and 7.8 mg/kg for female subjects (average 61.6 kg). Subjects were required to fast for four hours following administration to ensure absorption. The studies demonstrated that this dosage is safe and well-tolerated in healthy individuals, achieving effective plasma concentrations that are sustained for approximately 24 hours.
Note: Dosage may vary depending on specific product formulations and regulatory guidelines in target markets.
Safety of Mangiferin Powder
Current toxicological studies indicate that mangiferin possesses a favorable safety profile. In acute and 28-day subchronic toxicity studies, oral administration within the dose range of 250–1000 mg/kg revealed no observable clinical abnormalities, hematological irregularities, or significant organ damage, suggesting a low overall toxicity. However, prolonged exposure to ultra-high doses may induce changes—such as vacuolar degeneration and necrosis—within the exocrine tissue of the pancreas; consequently, careful attention to dose control remains essential.
Taken together, mangiferin demonstrates significant potential for application in the fields of dietary supplements, functional foods, pharmaceuticals, and cosmetics, nevertheless, for practical applications, it is recommended that safety assessments be conducted in conjunction with specific formulation designs and intended dosages.
Kintainutri® Mangiferin Powder Advantages?
As a professional supplier of botanical extract powders, we offer Mangiferin powder in various specifications ranging from 95% to 98% purity. To meet the diverse needs of our clients, Kintainutri® also provides customized packaging services, allowing us to tailor packaging specifications and styles according to your specific requirements. We boast an efficient logistics network and a rapid delivery system; orders placed immediately can be dispatched promptly, ensuring timely arrival. By choosing Kintainutri® for your Mangiferin needs, you gain access to high-quality products coupled with convenient and attentive service.
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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