Pharm Ingredients
Tetrahydrocurcumin Powder
Factory Price Tetrahydrocurcumin Powder
Kintainutri® is a leading supplier specializing in the research and production of plant extracts, dedicated to providing global customers with high-quality Tetrahydrocurcumin powder.
Partner with usfor competitive wholesale pricing, flexible MOQs, and reliable global logistics. Contact us today for a quote!
Partner with usfor competitive wholesale pricing, flexible MOQs, and reliable global logistics. Contact us today for a quote!
what is Tetrahydrocurcumin powder
Tetrahydrocurcumin is an colorless metabolite of curcumin, belonging to the hydrogenated derivatives of curcuminoids. Tetrahydrocurcumin, as a highly promising natural active substance, is widely favored in the cosmetic, food, and pharmaceutical industries due to its excellent stability, safety, and diverse efficacy. In the cosmetics sector, it is extensively used in skincare products for whitening, spot removal, and anti-aging, particularly suitable for colorless cosmetics. It also holds significant application potential in pharmaceutical intermediates and food additives, serving as an antioxidant to preserve product stability and extend shelf life.
Contact us Tetrahydrocurcumin vs Curcumin
| Curcumin | Tetrahydrocurcumin | |
|---|---|---|
| Source | Rhizome of turmeric | The hydrogenated metabolite of curcumin |
| Colour | Yellow | White |
Core Biological Activity
|
Anti-inflammatory, Anti-cancer, Antibacterial |
Anti-inflammatory, Anti-cancer, Neuroprotective, Whitening and repair |
| Molecular Structure | Contains conjugated double bonds | No double bonds (saturated structure) |
| Bioavailability | Low (fast metabolism, chemically unstable) | Significantly higher |
| Stability | Easily degradable | More stable (resistant to light and heat /PH changes |
| Antioxidant Ability | Effective, but high concentrations have a pro-oxidation effect | More potent and non-oxidizing |
| Application advantage fields | Food coloring, basic supplements | High-end skin care products/pharmaceuticals (no staining, high penetration) |
Tetrahydrocurcumin powder Production Process
1.Raw Material Pretreatment
Select high-quality Curcuma longa rhizomes, wash, then pulverize into 60-80 mesh particles to increase surface area for enhanced extraction efficiency.
2.Solvent Extraction of Curcumin
Perform supercritical CO₂ extraction or food-grade ethanol-water mixed solvent extraction under dynamic counter-current conditions at 45-60℃. Concentrate the extract to obtain curcumin crude extract (purity ≥90%).
3.Catalytic Hydrogenation Reaction
Dissolve curcumin in ethanol, add palladium-carbon (Pd/C) or platinum catalyst. React under hydrogen atmosphere (pressure 0.5-1.5 MPa, temperature 50-70℃) for 4-6 hours to complete hydrogenation of double bonds, forming tetrahydrocurcumin.
4.Purification and Refining
• Chromatographic separation: Use silica gel column chromatography with ethyl acetate/n-hexane gradient elution to remove by-products.
• Crystallization purification: Recrystallize in ethanol-water system to obtain white crystals (HPLC purity ≥98%).
5.Drying and Standardization
Vacuum freeze-dry (-40℃, moisture content ≤5%) to preserve activity. Sieve through 200 mesh, test antioxidant capacity (ORAC ≥150,000 μmol TE/g), and ensure heavy metals and microorganisms meet standards.
Kintainutri® Tetrahydrocurcumin Powder Advantages
R High Purity:
Kintainutri® Tetrahydrocurcumin uses high-purity curcumin (purity ≥98%) as raw material, produced via standardized processes including high-pressure hydrogenation reaction. Subsequent purification and stringent quality control ensure HPLC-detected purity ≥98%, with no heavy metals, residual solvents, or microbial contaminants, guaranteeing stable and reliable quality.
R Supply Ability:
As a factory-direct supplier, Kintainutri® has stable production capacity to meet bulk procurement needs.
R Premium Service:
We customize solutions based on client requirements for parameters such as purity, particle size, and packaging, catering to diverse needs.
R Stringent Quality Control System:
We have established a strict full-process and all-round quality control system from raw material procurement and production process to finished product delivery. Every batch is manufactured in strict compliance with international certifications such as GMP, ISO 9001, and ISO 22000.
Specification of Tetrahydrocurcumin powder
| ITEMS | Standards |
| Product common name | Tetrahydrocurcumin |
| CAS Number | 36062-04-1 |
| Assay | ≥96% (HPLC) |
| Molecular Weight | 372.4 |
| Appearance | Off-white powder |
| Melting Point | 95-97℃ |
| Boiling Point | 564.1℃ (Under 760mmHg conditions) |
| Solubility | Insoluble in water, soluble in organic solvents (methanol,ethanol, DMSO) |
| Heavy Metal | ≤20ppm |
| Arsenic (As) | ≤2ppm |
| Microbiology | |
| Total of bacteria | ≤1000cfu/g |
| Fungus | ≤100cfu/g |
| Salmonella | Negative |
| E.Coli | Negative |
| Conclusion: the test results conform to enterprise standards |
Tetrahydrocurcumin Powder Benefits
1.Metabolic Regulation-Related Effects
R Hypoglycemic:
Reduces blood glucose levels in diabetic mice and rats, increases insulin levels, demonstrating favorable hypoglycemic activity against type 2 diabetes, with superior efficacy compared to curcumin.
R Hypolipidemic:
Lowers serum and hepatic cholesterol, triglycerides in diabetic rats, restores regulatory enzymes involved in lipid and lipoprotein metabolism. Mechanisms may relate to enhanced insulin secretion and antioxidant activity.
R Anti-Fatty Liver:
Reduces hepatic lipid droplets, lowers liver index, intrahepatic lipids, and related enzyme levels, improves hepatic histopathology in a dose-dependent manner.
2.Antioxidant and Cell Protection
Enhances activities of multiple endogenous antioxidant enzymes, reduces oxidative stress levels, protects cells from lipid peroxidation damage, and ameliorates oxidant-induced stress responses.
3.Disease Prevention and Treatment-Related Effects
R Anticancer:
Inhibits carcinogenesis in colon cancer and other tumors, reduces metastatic potential of malignant cells, induces apoptosis in leukemic cells, exhibiting superior efficacy compared to curcumin.
R Antihypertensive:
Lowers blood pressure in nitric oxide-deficient hypertensive rats, improves aortic atherosclerosis.
R Anti-inflammatory:
Demonstrates anti-inflammatory activity, with superior efficacy to curcumin and certain compounds in comparative studies.
R Renal Protective:
Reduces urea, uric acid levels, decreases albuminuria and urine output in diabetic mice, preventing/treating diabetic complications.
R Antidepressant:
Exhibits dose-dependent antidepressant effects, potentially mediated through modulation of the monoaminergic neurotransmitter system.
Tetrahydrocurcumin Powder Applications
1.Cosmetics Industry
As a natural functional whitening ingredient, it inhibits tyrosinase activity and scavenges oxygen free radicals, making it suitable for the development of whitening, spot-removing, and anti-aging skincare products. Being a colorless substance, it can be adapted to colorless cosmetics, avoiding color interference from traditional raw materials.
2.Pharmaceutical Industry
Based on its multiple pharmacological effects including hypoglycemic, hypolipidemic, anti-fatty liver, anticancer, antidepressant, and renal protective properties, it can serve as a pharmaceutical intermediate for the research and development of drugs targeting related diseases, such as type 2 diabetes, hypertension, colon cancer, and depression.
3.Health Food Industry
With antioxidant and metabolic regulatory effects (e.g., lowering blood glucose and lipids), it can be added as a functional ingredient to health foods for assisting in the improvement of metabolic syndrome and enhancing the body’s antioxidant capacity.
4.Food Additive Industry
Possessing certain stability and safety, and being naturally derived, it can be used as a food-related additive to exert its functional value in the food sector.
Recommended Dosage of Tetrahydrocurcumin Powder
| Application Form | Suggested Dosage Range | Notes |
|---|---|---|
| Additive for skin care products | 0.1% to 0.5% (total formula content); 1-2 times a day |
It should be mixed with the base lotion/essence for use |
| Dietary Supplement | 250 to 500mg per day; Take once a day with meals |
Repackage into capsules or mix into beverages |
| High-concentration antioxidant | ≤800mg per day; Take it in two divided doses | Continuous use for no more than 8 weeks, with intervals for rest |
(Note: It is essential to refer to the relevant regulatory requirements specific to your intended use case.)
Safety of Tetrahydrocurcumin Powder
1.Allergic Reactions and Sensitivities
Tetrahydrocurcumin exhibits an extremely low incidence of allergic reactions in clinical and practical applications. Research indicates that whether taken orally or applied topically (e.g., in skincare products), the vast majority of the population does not experience allergic or irritation reactions. Its molecular structure, more stable than curcumin, further reduces irritation potential, making it suitable for most skin types and populations. For individuals with specific sensitivities (e.g., those allergic to turmeric), a localized patch test is recommended before initial use to ensure compatibility.
2. Safety and Toxicity Research
Multiple studies indicate that tetrahydrocurcumin demonstrates high safety:
★ Acute Toxicity: High-dose oral administration in animal studies showed no acute toxic reactions, with no defined lethal dose (LD50) identified, indicating extremely low acute toxicity.
★ Chronic Toxicity: Long-term low-dose intake or topical application studies revealed no damage to major organs (e.g., liver, kidneys, cardiovascular system) and no teratogenic, mutagenic, or carcinogenic effects.
★Metabolic Safety: Tetrahydrocurcumin has well-defined metabolic pathways in humans, primarily metabolized mildly by the liver with no risk of accumulative toxicity. Its metabolites are non-toxic to humans.
3. International Compliance Certifications
Tetrahydrocurcumin has obtained multiple international authoritative certifications, meeting global mainstream safety regulations:
★U.S. FDA: Comply with the safety requirements for food additives, dietary supplements, and cosmetic ingredients.
★EU EFSA : Comply with safety assessment standards, permitted for use in food, health supplements, and skincare products across EU member states.
★ICCR: Passed safety evaluations by the International Cosmetic Ingredient Standard Committee (ICCR), recognized as a safe cosmetic ingredient.
Why Choose Kintainutri®Tetrahydrocurcumin powder?
R High Quality Raw Materials; (naturally grown without any additives)
R Customized extraction solutions;
(produce tetrahydrocurcumin powder in various specifications tailored to your requirements）
R Internationally Recognized Certifications;
(including GMP, ISO 9001, ISO 22000, HACCP, KOSHER, and HALAL)
R Flexible Packaging & Logistics.
Packaging options from 1kg to 25kg using moisture-proof and light-resistant materials; support for multiple trade terms to ensure timely and safe delivery.
Choose Kintainutri®, and you will receive high-purity, high-quality, and cost-effective Tetrahydrocurcumin powder raw materials, as well as professional, reliable, and flexible cooperation experience! If you need samples or detailed information, please feel free to contact us at any time！
Shipping & Packaging
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● Packaging: Inside food grade bag, outer aluminum foil bag.25kg use double-layer plastic container/fiber drum.Or your choice.● OEM Service Available: Customized packaging available, click here to know more.● Shipping: DHL / FEDEX / EMS/ BY AIR / BY SEA● American Warehouse: KINTAI put over 100 natural plant extract ingredients in our US warehouse for fast delivery.● Payment: We accept payment by T/T, L/C, Paypal, and Wester Union.Please contact us and we will guide you with an easy and professional way for your order.
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